PhotoBioModulation Therapy

New therapy available at MindBody Medicine Center using an easy light applicator held under the tongue which is powered by PHOTONX

PhotoBioModulation (PBM) is the delivery of photonic energy (light) to cells in the body that has been shown to improve energy, manage stress, improve mobility and sharpen mental acuity. PBM can stimulate cells to work more efficiently and fluidly by exposing cells to specific peaks of photonic energy within the visible and near-infrared light spectrum.  One of the primary mechanisms of PBM is the stimulation of mitochondria, the energy powerhouse of the cell.1 Mitochondria produce adenosine triphosphate (ATP), which is an energy-carrying molecule found in the cells of all living things. The mitochondria capture chemical energy obtained from the breakdown of food molecules and releases ATP to fuel other cellular processes.2 Increasing ATP has positive effects on many systems within the body.

The Mechanism of Action of PhotoBioModulation?

PhotoBioModulation (PBM) is also referred to as Low Level Laser (or light) Therapy (LLLT). It is the molecular and cellular interactions and biological cascades resulting from exposure to specific wavelengths of photonic energy (light). These interactions utilize non-ionizing and non-thermal light sources, including lasers, light emitting diodes (LEDs), and/or broadband light to drive these biological responses.3  These wavelengths range from the visible range of 400–700nm to the near-infrared range of 700–1100nm on the electromagnetic spectrum.

PBM responses begin in the mitochondrial membrane of the electron transport chain, specifically with the enzyme cytochrome c-oxidase (CCO) complex IV.4  PhotoBioModulation synthesizes adenosine tri-phosphate (ATP).5,6 PBM also regulates reactive oxygen species (ROS or free radicals) and nitric oxide (NO) to restore or optimize mitochondrial function.7,8 Use of PBM has been studied and documented for alleviation of pain and inflammation, promotion of wound healing, tissue regeneration and increase of mental acuity.9,10 As the understanding of PBM mechanisms and benefits continues to improve, it has been the subject of over 6,000 peer-reviewed publications.11

PhotoBioModulation is a non-invasive, painless and affordable therapy.

Oxidative Stress

“Oxidative stress” is a term used to describe an imbalance in the body between antioxidants and free radicals.12 Free radicals are atoms and molecules that are highly reactive with other cellular structures because they contain unpaired electrons.13 This condition can cause damage to cells, proteins and DNA.

Additionally, free radicals are natural by-products of ongoing biochemical reactions in the body, including ordinary metabolic processes and immune system responses.

The body experiences oxidative stress on an ongoing basis because it maintains a certain amount of oxidative stress naturally.  This can be a natural reaction to an event that upsets the body’s balance, such as an injury or exposure to a pathogen or environmental toxins. Once the body responds to and resolves the stressor the body can return to a healthy balance, or equilibrium.14

However, when the immune system becomes overwhelmed and unable to restore equilibrium, oxidative stress becomes detrimental to the body. Inflammation and its related conditions are some of the most common results of oxidative stress.

By restoring oxidative balance, PBM reduces the biological drivers of inflammation.

PBM Energy (Light)

The Photonx Wellness Consoles are specially engineered photonic energy devices, capable of simultaneously delivering multiple, specific wavelengths of photonic energy.  The system delivers peak wavelengths within the visible and near-infrared spectrum. These wavelengths include 405nm, 530nm, 630nm, 660nm, and 810nm.

Photonx PBM Claims

  • Improve Energy
  • Manage Stress
  • Improve Mobility
  • Sharpen Mental Acuity

Photonx PBM Benefits

  • Non-Invasive
  • Easy-to-Use
  • Personalized PBM Sessions

Improve Energy

Photonx PhotoBioModulation (PBM) helps improve cellular energy through the activation of the mitochondria to synthesize ATP.15,16 PBM’s mechanism stimulates cellular energy production.17,18

Manage Stress

The body experiences many types of stress: Physical, environmental, mental and emotional. These events manifest themselves in stress at the cellular level (oxidative stress).  The body’s cells respond to stress by modulating free radicals (ROS) to recreate a balanced state.19

Oxidative stress decreases synthesis of ATP, the body’s source of cellular energy.20 This energy powers the immune system to protect against infection, disease and inflammation.21

PBM regulates the amount of free radicals in the body, stimulating the body to produce levels of reactive oxygen species (ROS) and ATP while releasing nitric oxide (NO).22,23 This allows the body to reduce oxidative stress to promote a better immune and healing response.24,25

Improve Mobility

One of the signs of oxidative stress in the body is upregulation of inflammatory markers.26 PBM has been shown to reduce inflammatory markers and increase range of motion.27 PBM restores balance to unstable electrons to relieve the body of the cellular stress and its effects.28 This includes the inflammatory markers that impair mobility and restrict range of motion; thus, improving mobility.

Sharpen Mental Acuity

PBM has been shown to increase mental acuity and sharpen cognitive function. In the brain, PBM increases cellular energy (ATP), cerebral blood flow, mitochondrial activity and enhances brain oxygenation.29 Additionally, PBM decreases cerebral inflammation and oxidative stress.30 This allows for sharpened memory, quicker response times and improved concentration.31

PBM Therapy Sessions

The Photonx Wellness Consoles emit specific wavelengths of photonic energy delivered through revolutionary PBM technology. Once you arrive at {insert your clinic name}, you will use your 5-click Sublingual Applicator to plug into the Photonx Wellness Console. Then, you will be able to choose a blend of different wavelengths to personalize your wellness experience. You will have your own Sublingual Applicator (5-click). To receive more PBM sessions, contact {insert Dr. name} for more information.

For research on specific wavelength or session recommendations, please visit photonxwellness.com

References

  1. Hamblin MR. Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation. Photochem Photobiol. 2018;94(2):199-212. doi:10.1111/php.12864
  2. Osellame LD, Blacker TS, Duchen MR. Cellular and molecular mechanisms of mitochondrial function. Best Pract Res Clin Endocrinol Metab. 2012;26(6):711-723. doi:10.1016/j.beem.2012.05.003
  3. Anders JJ, Lanzafame RJ, Arany PR. Low-level light/laser therapy versus photobiomodulation therapy. Photomed Laser Surg. 2015;33(4):183-184. doi:10.1089/pho.2015.9848
  4. de Freitas LF, Hamblin MR. Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy. IEEE J Sel Top Quantum Electron. 2016;22(3):7000417. doi:10.1109/JSTQE.2016.2561201
  5. Mvula B, Moore TJ, Abrahamse H. Effect of low-level laser irradiation and epidermal growth factor on adult human adipose-derived stem cells. Lasers Med Sci. 2010; 25 (1):33–39. doi: 10.1007/s10103-008-0636-1.
  6. Sivapathasuntharam C, Sivaprasad S, Hogg C, Jeffery G. Aging retinal function is improved by near infrared light (670 nm) that is associated with corrected mitochondrial decline. Neurobiol Aging. 2017; 52:66–70. doi:10.1016/j.neurobiolaging.2017.01.001
  7. Kumar Rajendran N, George BP, Chandran R, Tynga IM, Houreld N, Abrahamse H. The Influence of Light on Reactive Oxygen Species and NF-кB in Disease Progression. Antioxidants (Basel). 2019;8(12):640. Published 2019 Dec 12. doi:10.3390/antiox8120640
  8. de Freitas LF, Hamblin MR. Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy. IEEE J Sel Top Quantum Electron. 2016;22(3):7000417. doi:10.1109/JSTQE.2016.2561201
  9. Hamblin MR. Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation. Photochem Photobiol. 2018;94(2):199-212. doi:10.1111/php.12864
  10. Zhang J, Yue X, Luo H. Illumination with 630 nm red light reduces oxidative stress and restores memory by photo-activating catalase and formaldehyde dehydrogenase in SAMP8 mice. Antioxid Redox Signal. 2019; 30(11):1432-1449. doi: 10.1089/ars.2018.7520.
  11. Serrage H, Heiskanen V, Palin W, et al. Under the spotlight: Mechanisms of photobiomodulation concentrating on blue and green light. Photochem Photobiol Sci. 2019;8(8):1877-1909.
  12. Liguori I, Russo G, Curcio F, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018;13:757-772. Published 2018 Apr 26. doi:10.2147/CIA.S158513
  14. de Lima FM, Albertini R, Dantas Y, et al. Low-level laser therapy restores the oxidative stress balance in acute lung injury induced by gut ischemia and reperfusion.Photochem Photobiol. 2013;89(1):179-188. doi:10.1111/j.1751-1097.2012.01214.x
  15. Sivapathasuntharam C, Sivaprasad S, Hogg C, Jeffery G. Aging retinal function is improved by near infrared light (670 nm) that is associated with corrected mitochondrial decline. Neurobiol Aging. 2017; 52:66–70. doi:10.1016/j.neurobiolaging.2017.01.001
  16. Mvula B, Moore TJ, Abrahamse H. Effect of low-level laser irradiation and epidermal growth factor on adult human adipose-derived stem cells. Lasers Med Sci. 2010; 25 (1):33–39. doi: 10.1007/s10103-008-0636-1.
  17. Sivapathasuntharam C, Sivaprasad S, Hogg C, Jeffery G. Aging retinal function is improved by near infrared light (670 nm) that is associated with corrected mitochondrial decline. Neurobiol Aging. 2017; 52:66–70. doi:10.1016/j.neurobiolaging.2017.01.001
  18. Mvula B, Moore TJ, Abrahamse H. Effect of low-level laser irradiation and epidermal growth factor on adult human adipose-derived stem cells. Lasers Med Sci. 2010; 25 (1):33–39. doi: 10.1007/s10103-008-0636-1
  19. Hussain T, Tan B, Yin Y, Blachier F, Tossou MC, Rahu N. Oxidative Stress and inflammation: What polyphenols can do for us?Oxid Med Cell  2016;2016:7432797. doi:10.1155/2016/7432797
  20. Pacheu-Grau D, Rucktäschel R, Deckers M. Mitochondrial dysfunction and its role in tissue-specific cellular stress. Cell Stress. 2018;2(8):184-199. Published 2018 Jul 13. doi:10.15698/cst2018.07.147
  21. Walker MA, Volpi S, Sims KB, Walter JE, Traggiai E. Powering the immune system: mitochondria in immune function and deficiency. J Immunol Res. 2014;2014:164309. doi:10.1155/2014/164309
  22. Kumar Rajendran N, George BP, Chandran R, Tynga IM, Houreld N, Abrahamse H. The Influence of Light on Reactive Oxygen Species and NF-кB in Disease Progression. Antioxidants (Basel). 2019;8(12):640. Published 2019 Dec 12. doi:10.3390/antiox8120640
  23. de Freitas LF, Hamblin MR. Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy. IEEE J Sel Top Quantum Electron. 2016;22(3):7000417. doi:10.1109/JSTQE.2016.2561201
  24. Walker MA, Volpi S, Sims KB, Walter JE, Traggiai E. Powering the immune system: mitochondria in immune function and deficiency. J Immunol 2014;2014:164309. doi:10.1155/2014/164309
  25. Figurová M, Ledecký V, Karasová M, et al. Histological assessment of a combined low- level laser/light-emitting diode therapy (685 nm/ 470 nm) for sutured skin incisions in a porcine model: a short report. Photomed Laser Surg. 2016; 34(2): 53–55. doi: 10.1089/pho.2015.4013.
  26. Liguori I, Russo G, Curcio F, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018;13:757-772. Published 2018 Apr 26. doi:10.2147/CIA.S158513
  27. Alves AC, Vieira R, Leal-Junior E, et al. Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation. Arthritis Res Ther. 2013;15(5):R116. doi:10.1186/ar4296
  28. Kim HP. Lightening up Light Therapy: Activation of Retrograde Signaling Pathway by Photobiomodulation. Biomol Ther (Seoul). 2014;22(6):491-496. doi:10.4062/biomolther.2014.083
  29. Hamblin MR. Shining light on the head: Photobiomodulation for brain disorders. BBA Clin. 2016;6:113-124. Published 2016 Oct 1. doi:10.1016/j.bbacli.2016.09.002
  31. Naeser MA, Saltmarche A, Krengel MH, Hamblin MR, Knight JA. “Transcranial LED therapy for cognitive dysfunction in chronic, mild traumatic brain injury: Two case reports”, SPIE 7552, Mechanisms for Low-Light Therapy V, 75520L (25 February 2010); doi:10.1117/12.842510